Onion or beneficial treatment for ovarian cancer-zuczug

As everyone knows for onions or beneficial to the treatment of ovarian cancer is beneficial to onion or ovarian cancer, by regulating the tumor microenvironment of tumor associated macrophages (TAMs) in tumor play an important role in the development of M2, polarized targeting TAMs before tumor activation or TAMs is expected to become the effective method for treatment of cancer patients. Previous studies have shown that onion A (ONA), a natural low molecular weight compound isolated from onion, can inhibit the polarization of M2 macrophages. In this study, the researchers aimed to investigate whether ONA has an anti ovarian cancer effect in vivo and in vitro. The results showed that ONA could reduce the proliferation of Del ovarian cancer cells induced by co culture with macrophages. In addition, the researchers also found that ONA can directly inhibit the proliferation of cancer cells. The combination of ONA and anticancer drugs is also effective. ONA in ovarian cancer cells can significantly inhibit the activation of signal transduction and transcription factor 3 (STAT3, which is related to cell proliferation and chemoresistance). In addition, single or combined therapy can inhibit tumor progression and prolong survival time in mouse ovarian cancer models. Therefore, ONA may be an additional therapy for ovarian cancer.

洋葱或有益于卵巢癌的治疗洋葱或有益于卵巢癌的治疗众所周知,通过调节肿瘤微环境肿瘤相关巨噬细胞(TAMs)在肿瘤的发生发展中发挥着重要的作用,靶向TAMs的前肿瘤激活或TAMs的M2极化有望成为癌症患者有效的治疗方法。本实验组既往研究表明,洋葱素A(ONA)——从洋葱中分离的天然低分子量化合物,可抑制M2巨噬细胞的极化。本研究中,研究人员旨在探究体内及体外研究中ONA是否有抗卵巢癌的作用。结果发现,ONA可减少与巨噬细胞共培养诱导德尔卵巢癌细胞的增殖程度。此外,研究人员还发现,ONA可直接抑制癌细胞的增殖。ONA与抗癌药物组合同样也由此效果。卵巢癌细胞中的ONA可显著抑制信号转导与转录因子3(STAT3,与细胞增殖和化疗耐药有关)的激活。此外,在小鼠卵巢癌模型中使用单一或联合治疗可抑制肿瘤进展,延长小鼠存活时间。因此,ONA或可作为卵巢癌治疗的附加疗法。相关的主题文章:

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