Onion or beneficial treatment for ovarian cancer-zuczug

As everyone knows for onions or beneficial to the treatment of ovarian cancer is beneficial to onion or ovarian cancer, by regulating the tumor microenvironment of tumor associated macrophages (TAMs) in tumor play an important role in the development of M2, polarized targeting TAMs before tumor activation or TAMs is expected to become the effective method for treatment of cancer patients. Previous studies have shown that onion A (ONA), a natural low molecular weight compound isolated from onion, can inhibit the polarization of M2 macrophages. In this study, the researchers aimed to investigate whether ONA has an anti ovarian cancer effect in vivo and in vitro. The results showed that ONA could reduce the proliferation of Del ovarian cancer cells induced by co culture with macrophages. In addition, the researchers also found that ONA can directly inhibit the proliferation of cancer cells. The combination of ONA and anticancer drugs is also effective. ONA in ovarian cancer cells can significantly inhibit the activation of signal transduction and transcription factor 3 (STAT3, which is related to cell proliferation and chemoresistance). In addition, single or combined therapy can inhibit tumor progression and prolong survival time in mouse ovarian cancer models. Therefore, ONA may be an additional therapy for ovarian cancer.


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